Agarose-based chromatography resin supports purification of oligonucleotides and peptides for biopharma applications

WILMINGTON, Del., May 22, 2025 /PRNewswire/ -- DuPont has expanded its bioprocessing portfolio with the launch of DuPont™ AmberChrom™ TQ1 chromatography resin for the purification of oligonucleotides and peptides in support of a wide-range of biopharma applications.DuPont Logo (PRNewsfoto/DuPont)

"The introduction of DuPont™ AmberChrom™ TQ1 chromatography resin supports the accelerated development and commercialization of oligonucleotide and peptide therapeutics," said Shane Kendra, Global Bioprocessing Market Leader for DuPont Water Solutions. "In addition to expanding our capabilities, this new anion exchange chromatography resin offers exceptional performance, setting a new standard in this product class and creating new opportunities in high growth therapy areas."

The new agarose-based chromatography resin offers increased loading capacity, higher throughput, and requires less pressure than comparable competing products within the same class. These characteristics make DuPont™ AmberChrom™ TQ1 chromatography resin an excellent choice for high resolution separations and polishing, offering high purity fractions in biomolecule purifications and the separation of closely-related impurities from target molecules. Its low-pressure build-up, combined with high-yield and purity for peptides and both DMT-Off and DMT-On oligonucleotides, makes the resin suitable for use in benchtop and large-scale commercial purifications.

To support the introduction of the resin, DuPont has published comprehensive internal application studies that used real-world drug feeds to validate performance characteristics; this documentation can also assist with the integration of the product into processes at every phase from drug discovery through commercialization.

"Further expansion of DuPont's bioprocessing portfolio reflects our commitment to providing a comprehensive one-stop shop for the purification and polishing of oligonucleotides and peptides," said Kendra. "Our technical teams and scientists are continually collaborating with customers to design efficient bioprocessing solutions for every stage of the drug development journey."

DuPont™ AmberChrom™ TQ1 chromatography resin can be used in combination with existing AmberChrom™ XT and CG chromatography resins to purify various oligonucleotide feeds, or for the crude purification of peptide feeds in preparation for reverse phase chromatography.

DuPont introduced the new chromatography resin to the market during TIDES USA—a conference dedicated to accelerating oligonucleotide and peptide innovations. Hadi Fares, Ph.D, a bioprocessing application scientist with DuPont, presented application studies to demonstrate the performance capabilities of DuPont™ AmberChrom™ TQ1 chromatography resin, and how it complements existing resins within the DuPont bioprocessing portfolio.

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On June 19, 2025, DuPont will host an educational webinar discussing the capabilities of  DuPont™ AmberChrom™ TQ1 chromatography resin and how its loading capacity and purification efficacy can enhance purification of oligonucleotides and peptides. Register here.

Learn more about DuPont™ AmberChrom™ TQ1 chromatography resin and the broader DuPont bioprocessing portfolio.

As a global market leader in adsorbents and ion exchange resins with over 80 years of experience, DuPont bioprocessing solutions can accelerate and enhance the discovery and production of small molecule synthetics, oligonucleotides, and peptides, as well as diagnostics, by enabling complicated separations that help companies achieve their vision to manage and treat diseases.

About DuPont DuPont (NYSE: DD) is a global innovation leader with technology-based materials and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets including electronics, transportation, construction, water, healthcare and worker safety. More information about the company, its businesses and solutions can be found at www.dupont.com. Investors can access information included on the Investor Relations section of the website at investors.dupont.com.

DuPont™, the DuPont Oval Logo, and all trademarks and service marks denoted with ™, SM or ® are owned by affiliates of DuPont de Nemours, Inc. unless otherwise noted.Cision

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SOURCE DuPont

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