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Alector, Inc., a clinical stage biotechnology company, develops therapies to counteract the progression of neurodegeneration in the United States. Its pipeline includes Nivisnebart, an investigational human recombinant monoclonal antibody for treating prevalent neurodegenerative diseases; AL137, an anti-amyloid beta antibody paired in preclinical development for the potential treatment of Alzheimer's disease; and AL050, a GCase enzyme replacement therapy in preclinical development for the potential treatment of Parkinson's disease and Lewy body dementia in patients having GBA1 gene mutations. The company also develops its preclinical and research pipeline comprising AL064, a tau siRNA for Alzheimer's disease and other tauopathies; ADP062-ABC, an alpha-synuclein siRNA for Parkinson's disease; and ADP065-ABC, an NLRP3 siRNA for neurodegenerative conditions. It has a strategic collaboration agreement with GlaxoSmithKline plc for the development and commercialization of progranulin-elevating monoclonal antibodies, including Latozinemab and Nivisnebart. The company was founded in 2013 and is headquartered in South San Francisco, California.
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Alector Inc is a clinical-stage biopharma developing immunology-based therapies for neurodegenerative diseases by modulating the brain's innate immune system. Growth drivers include clinical program readouts, potential approvals in underserved CNS indications, and biomarker-driven patient selection that could support trial success. Investors may find the company attractive for its differentiated science and concentrated pipeline addressing high unmet need.
Primary investment risks are significant clinical and regulatory uncertainty, ongoing cash burn with likely need for additional financing, and competition from other CNS programs that could limit market opportunity.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -142.76M | -118.92M | -125.18M | -130.06M | -36.33M |
| Net income | -142.93M | -119.05M | -130.39M | -133.31M | -28.01M |
| Selling general administrative | 53.99M | 59.62M | 56.69M | 61.03M | 55.04M |
| Gross profit | 11.38M | 100.56M | 88.21M | 133.62M | 207.09M |
| Reconciled depreciation | 9.66M | 8.84M | 8.70M | 8.47M | 8.31M |
| Ebit | -142.76M | -145.00M | -151.74M | -146.31M | -45.67M |
| Ebitda | -133.10M | -136.16M | -142.89M | -137.83M | -37.36M |
| Depreciation and amortization | 9.66M | 8.84M | 8.85M | 8.47M | 8.31M |
| Non operating income net other | - | - | - | - | 1.03M |
| Operating income | -145.81M | -145.00M | -151.74M | -137.83M | -37.36M |
| Other operating expenses | 166.85M | 245.56M | 248.80M | 271.45M | 244.44M |
| Interest expense | - | - | - | -16.25M | 8.31M |
| Tax provision | 0.17M | 0.13M | 4.27M | 3.25M | - |
| Income tax expense | 0.17M | 0.13M | 5.21M | 3.25M | -8.31M |
| Total revenue | 21.05M | 100.56M | 97.06M | 133.62M | 207.09M |
| Total operating expenses | 157.19M | 245.56M | 239.95M | 271.45M | 244.44M |
| Cost of revenue | 9.66M | 8.84M | 8.85M | - | - |
| Total other income expense net | 3.05M | 26.08M | 26.56M | 7.78M | 1.03M |
| Net income from continuing ops | -142.93M | -119.05M | -141.38M | -133.31M | -36.33M |
| Net income applicable to common shares | - | - | - | -133.31M | -36.33M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 293.24M | 468.30M | 621.83M | 787.65M | 814.66M |
| Other current assets | 10.43M | 11.42M | 16.95M | 11.00M | 7.07M |
| Total liab | 262.59M | 341.50M | 487.67M | 573.21M | 513.93M |
| Total stockholder equity | 30.65M | 126.80M | 134.16M | 214.44M | 300.72M |
| Other current liab | 51.71M | 90.43M | 82.74M | -14.90M | -55.13M |
| Common stock | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Capital stock | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Retained earnings | -972.06M | -829.13M | -710.08M | -579.69M | -446.38M |
| Other liab | - | - | - | 444.13M | 334.57M |
| Other assets | - | - | - | 7.88M | 7.05M |
| Cash | 65.80M | 33.02M | 74.56M | 154.32M | 329.15M |
| Total current liabilities | 69.50M | 125.06M | 177.95M | 45.58M | 48.22M |
| Current deferred revenue | 6.68M | 23.66M | 82.97M | 48.23M | 90.80M |
| Net debt | -29.57M | 9.50M | -35.64M | -111.00M | -281.55M |
| Short term debt | 9.42M | 8.75M | 8.46M | 8.06M | 7.79M |
| Short long term debt | 0.37M | - | - | - | - |
| Short long term debt total | 36.23M | 42.52M | 38.92M | 43.33M | 47.60M |
| Other stockholder equity | 1002.53M | 955.66M | 844.04M | 798.70M | 748.04M |
| Property plant equipment | - | - | - | 53.33M | 27.33M |
| Total current assets | 266.45M | 424.82M | 565.81M | 726.43M | 749.71M |
| Net tangible assets | - | - | - | 214.44M | 300.72M |
| Short term investments | 190.22M | 380.38M | 474.31M | 558.53M | 406.10M |
| Net receivables | - | - | - | 2.59M | 7.39M |
| Long term debt | 9.32M | 9.39M | - | - | - |
| Accounts payable | 1.69M | 2.21M | 3.77M | 4.19M | 4.75M |
| Accumulated other comprehensive income | 0.17M | 0.26M | 0.18M | -4.58M | -0.94M |
| Common stock total equity | - | - | - | - | 0.01M |
| Retained earnings total equity | - | - | - | - | -446.38M |
| Non currrent assets other | 2.23M | 6.39M | 7.42M | 7.88M | 7.05M |
| Non current assets total | 26.79M | 43.49M | 56.02M | 61.21M | 64.94M |
| Capital lease obligations | 26.54M | 33.13M | 38.92M | 43.33M | 47.60M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 196.64M | 107.13M | 102.23M | -159.01M | -46.42M |
| Change to liabilities | - | - | - | 65.81M | 1.60M |
| Total cashflows from investing activities | 196.60M | 107.13M | 101.92M | -159.01M | -49.66M |
| Net borrowings | 0.00M | 9.39M | 0.00M | - | - |
| Total cash from financing activities | 20.21M | 81.54M | 2.55M | 4.51M | 30.30M |
| Change to operating activities | - | - | - | -6.29M | -11.15M |
| Net income | -142.93M | -119.05M | -130.39M | -133.31M | -36.33M |
| Change in cash | 32.78M | -41.23M | -79.69M | -174.83M | 279.18M |
| Begin period cash flow | 34.87M | 76.10M | 155.79M | 330.62M | 51.44M |
| End period cash flow | 67.65M | 34.87M | 76.10M | 155.79M | 330.62M |
| Total cash from operating activities | -184.03M | -229.91M | -184.16M | -20.33M | 298.55M |
| Issuance of capital stock | 19.98M | 71.11M | 0.00M | 0.00M | 0.00M |
| Depreciation | -0.86M | 8.84M | 8.85M | 8.47M | 8.31M |
| Change to inventory | - | - | -2.59M | - | - |
| Change to account receivables | - | - | 2.59M | - | - |
| Sale purchase of stock | - | - | - | - | 30.30M |
| Other cashflows from financing activities | 0.22M | 1.04M | 2.55M | 1.46M | 30.30M |
| Change to netincome | - | - | - | 44.98M | 40.78M |
| Capital expenditures | 0.04M | 1.25M | 2.38M | 4.12M | 3.25M |
| Cash flows other operating | - | - | - | - | 284.06M |
| Cash and cash equivalents changes | - | - | - | - | 279.18M |
| Change in working capital | -74.06M | -146.99M | -90.15M | 59.53M | 283.68M |
| Stock based compensation | 26.66M | 39.46M | 42.80M | 46.15M | 40.78M |
| Other non cash items | 7.16M | -12.17M | -15.27M | -1.16M | 2.10M |
| Free cash flow | -184.07M | -231.16M | -186.54M | -24.45M | 295.30M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| ALEC Alector Inc |
-0.12 4.75% |
2.50 | - | 8.47 | 12.90 | 9.74 | 3.74 | -8.40 |
| NVO Novo Nordisk A/S |
-0.54 1.32% |
40.55 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-2.37 0.43% |
544.66 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
-2.77 0.29% |
956.64 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Alector, Inc., a clinical stage biotechnology company, develops therapies to counteract the progression of neurodegeneration in the United States. Its pipeline includes Nivisnebart, an investigational human recombinant monoclonal antibody for treating prevalent neurodegenerative diseases; AL137, an anti-amyloid beta antibody paired in preclinical development for the potential treatment of Alzheimer's disease; and AL050, a GCase enzyme replacement therapy in preclinical development for the potential treatment of Parkinson's disease and Lewy body dementia in patients having GBA1 gene mutations. The company also develops its preclinical and research pipeline comprising AL064, a tau siRNA for Alzheimer's disease and other tauopathies; ADP062-ABC, an alpha-synuclein siRNA for Parkinson's disease; and ADP065-ABC, an NLRP3 siRNA for neurodegenerative conditions. It has a strategic collaboration agreement with GlaxoSmithKline plc for the development and commercialization of progranulin-elevating monoclonal antibodies, including Latozinemab and Nivisnebart. The company was founded in 2013 and is headquartered in South San Francisco, California.
131 Oyster Point Boulevard, South San Francisco, CA, United States, 94080
415 231 5660
103
| Name | Title | Year Born |
|---|---|---|
| Dr. Tillman Ulf Gerngross Ph.D. | Co-Founder & Chairman | 1964 |
| Dr. Arnon Rosenthal Ph.D. | Co-Founder, CEO & Director | 1956 |
| Dr. Sara Kenkare-Mitra Ph.D. | Pres and Head of R&D | 1968 |
| Mr. Calvin Yu | VP of Fin. | 1976 |
| Dr. Marc Grasso M.D. | Chief Financial Officer | 1974 |
| Mr. Peter Heutink Ph.D. | Chief Scientific Officer | NA |
| Michelle Corral | VP of Communications & Investor Relations | NA |
| Ms. Danielle Pasqualone J.D., Ph.D. | Gen. Counsel | NA |
| Erica Jefferson | VP of Communications & Public Affairs | NA |
| Ms. Clare Hunt M.B.A. | Chief People Officer | NA |
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