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Actuate Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops therapies for the treatment of cancers in the United States. The company's lead product candidate is elraglusib injection, a glycogen synthase kinase-3 inhibitor that is in Phase 2 trial to treat metastatic pancreatic ductal adenocarcinoma. It also develops elraglusib, which is in Phase 1/2 trial for the treatment of refractory pediatric malignancies, including Ewing sarcoma, as well as neuroblastoma and pediatric leukemias. The company was formerly known as Apotheca Therapeutics, Inc. and changed its name to Actuate Therapeutics, Inc. in October 2015. Actuate Therapeutics, Inc. was incorporated in 2015 and is headquartered in Fort Worth, Texas.
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Actuate Therapeutics, Inc. is a Nasdaq-listed biopharmaceutical company focused on developing oncology therapies; public disclosures are limited but the company appears positioned as a clinical-stage drug developer. Long-term growth drivers may include positive clinical trial outcomes, strategic partnerships or licensing, and regulatory approvals that could support pipeline advancement and future commercialization. Investors may find interest in the potential upside tied to clinical milestones.
Key risks include high clinical and regulatory failure risk, substantial ongoing capital requirements and potential dilution, competitive pressures from larger oncology firms, and limited liquidity typical of small-cap biotech stocks.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
| Income before tax | -22.23M | -27.28M | -24.74M | -20.16M |
| Net income | -22.23M | -27.29M | -24.74M | -20.16M |
| Selling general administrative | 12.20M | 6.48M | 3.27M | 3.82M |
| Ebit | - | -27.30M | - | - |
| Ebitda | -22.50M | -25.16M | - | - |
| Depreciation and amortization | - | 2.14M | - | - |
| Operating income | -22.50M | -25.16M | -24.97M | -20.21M |
| Other operating expenses | 22.49M | 25.16M | - | - |
| Interest expense | 0.02M | 0.02M | 0.04M | 0.02M |
| Interest income | 0.29M | 0.22M | 0.35M | 0.03M |
| Net interest income | 0.27M | 0.20M | 0.31M | 0.01M |
| Income tax expense | 0.00M | 0.00M | - | - |
| Total revenue | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 22.50M | 25.16M | 24.97M | 20.21M |
| Total other income expense net | 0.27M | -2.12M | -0.08M | 0.04M |
| Net income from continuing ops | -22.23M | -27.29M | -24.74M | -20.16M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
| Total assets | 14.04M | 9.32M | 3.00M | 20.48M |
| Other current assets | 0.48M | 0.57M | 0.04M | 0.03M |
| Total liab | 6.11M | 9.21M | 102.62M | 95.79M |
| Total stockholder equity | 7.92M | 0.10M | -99.63M | -75.31M |
| Other current liab | 4.18M | 6.88M | - | - |
| Common stock | 0.00M | 0.00M | - | - |
| Capital stock | 0.00M | 0.00M | 0.00M | 0.00M |
| Retained earnings | -154.61M | -132.38M | -105.09M | -80.35M |
| Cash | 13.16M | 8.64M | 2.96M | 20.45M |
| Total current liabilities | 5.71M | 8.80M | 6.92M | 4.34M |
| Net debt | -12.75M | -8.64M | - | - |
| Short long term debt total | 0.40M | 0.40M | - | - |
| Other stockholder equity | 162.53M | 132.48M | - | - |
| Total current assets | 13.64M | 9.21M | 3.00M | 20.48M |
| Accounts payable | 1.52M | 1.92M | 3.42M | 2.13M |
| Non currrent assets other | 0.39M | 0.11M | - | - |
| Non current assets total | 0.39M | 0.11M | 0.00M | 0.00M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 |
| Net borrowings | 0.00M | 5.50M | - | - |
| Total cash from financing activities | 23.72M | 27.53M | 4.13M | 19.26M |
| Net income | -22.23M | -27.29M | -24.74M | -20.16M |
| Change in cash | 4.52M | 5.68M | -17.49M | 1.46M |
| Begin period cash flow | 8.64M | 2.96M | 20.45M | 18.99M |
| End period cash flow | 13.16M | 8.64M | 2.96M | 20.45M |
| Total cash from operating activities | -19.21M | -21.84M | -21.63M | -17.79M |
| Issuance of capital stock | 23.99M | 23.96M | 4.13M | 19.26M |
| Sale purchase of stock | - | 0.49M | - | - |
| Other cashflows from financing activities | -0.30M | -1.93M | - | - |
| Capital expenditures | 0.00M | 0.00M | 0.00M | 0.00M |
| Change in working capital | -3.05M | 1.10M | 2.57M | 1.73M |
| Stock based compensation | 6.05M | 2.00M | 0.42M | 0.65M |
| Other non cash items | 0.02M | 2.35M | 0.04M | 0.02M |
| Free cash flow | -19.21M | -21.84M | -21.63M | -17.79M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
|---|---|---|---|---|---|---|
| ACTU Actuate Therapeutics, Inc. Common stock |
0.01 1.67% |
0.33 | - | - | - | 7.84 |
| NVO Novo Nordisk A/S |
0.47 1.18% |
40.78 | 41.58 | 31.15 | 2.13 | 32.99 |
| VRTX Vertex Pharmaceuticals Inc |
0.34 0.06% |
547.43 | 30.22 | 24.27 | 10.36 | 6.50 |
| REGN Regeneron Pharmaceuticals Inc |
8.76 0.97% |
913.11 | 29.07 | 20.12 | 7.57 | 3.82 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 |
Actuate Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops therapies for the treatment of cancers in the United States. The company's lead product candidate is elraglusib injection, a glycogen synthase kinase-3 inhibitor that is in Phase 2 trial to treat metastatic pancreatic ductal adenocarcinoma. It also develops elraglusib, which is in Phase 1/2 trial for the treatment of refractory pediatric malignancies, including Ewing sarcoma, as well as neuroblastoma and pediatric leukemias. The company was formerly known as Apotheca Therapeutics, Inc. and changed its name to Actuate Therapeutics, Inc. in October 2015. Actuate Therapeutics, Inc. was incorporated in 2015 and is headquartered in Fort Worth, Texas.
1751 River Run, Fort Worth, TX, United States, 76107
817 887 8455
12
| Name | Title | Year Born |
|---|---|---|
| Mr. Daniel M. Schmitt | CEO, President & Director | 1962 |
| Dr. Andrew P. Mazar Ph.D. | Co-Founder & COO | 1962 |
| Dr. Alan Kozikowski Ph.D. | Scientific Founder and Advisor | 1951 |
| Mr. Paul J. Lytle CPA | Chief Financial Officer | 1968 |
| Dr. Alan Kozikowski Ph.D. | Scientific Founder and Advisor | 1950 |
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